Instrument Network and Security

Refer to Illumina Instrument Control Computer Security and Networking for further information on instrument security and network connections. The following sections include security and networking information specific to the NovaSeq 6000Dx .

Illumina does not install or provide technical support for network connections. Review network maintenance activities for potential compatibility risks with the NovaSeq 6000Dx Instrument.

Use the following guidelines to install and configure a network connection:

• Use a dedicated 1 gigabit connection between the instrument and data management system. Make this connection directly or through a network switch.
• Required bandwidth for a connection is as follows.
– 200 Mb/s/instrument for internal network uploads.
– 200 Mb/s/instrument for BaseSpace Sequence Hub network uploads.
– 5 Mb/s/instrument for Instrument Operational Data uploads.
• Switches must be managed.
• Network equipment such as switches must have a minimum capacity of 1 gigabit per second.
• Calculate the total capacity of the workload on each network switch. The number of connected instruments and ancillary equipment, such as a printer, can impact capacity.
• If possible, isolate sequencing traffic from other network traffic.
• Illumina recommends the use of CAT-6 cables (minimum requirement is CAT-5e). A shielded network cable that is 3 meters (9.8 feet) long is provided with the instrument for network connections.

For the system to function properly, reserve the IP ranges 169.254/16 and IPv6 fddc:65e5:66fa::*.

Network Illustration

NOTE

The CE is not visible on the host network.

Internal Connections

Connection

Value

Purpose

Domain

localhost:*

All ports for localhost-to-localhost communication, which are needed for interprocess communication.
 

Port

5555

Hardware controller interface

9030

Real-Time Analysis

8080

NovaSeq Operating Software

29644

Universal Copy Service

22, 80, 111, 443, 623, 2049, 5900, 8889, 9980, fddc:65e5:66fa::1/48, fddc:65e5:66fa::2/48

Data transfer

29000

Instrument orchestrator

Outbound connection information includes domain and IP address information for configuring access to BaseSpace Sequence Hub domains, Illumina Proactive, software updates, and uploads of run and performance data.

IP Addresses and Ports

Component

TCP

UDP

IP

BMC

22,80,443,623,5900,8889

623

169.254.0.2

NFS

111,2049

111,2049

fddc:65e5:66fa::2/48

fddc:65e5:66fa::1/48

CE

22,9980

n/a

169.254.0.1

Hardware Controllers

n/a

n/a

169.254.x.x/16