Replace Manifest Files and Cluster Files

1. Go to the Illumina support page for the BeadChip that you are using, and click the Downloads tab.
2. Download the files to be replaced or updated, and copy the files to your preferred network location.

Make sure that you select manifest and cluster files that are compatible with the NextSeq 550 system. Compatible files include NS550 in the file name.

3. Only if the location has changed, update the location on the BeadChip Scan Configuration screen, as follows:
a. From the NCS Home screen, select Manage Instrument.
b. Select System Configuration.
c. Select BeadChip Scan Configuration.
4. Select Browse and navigate to the location of the replaced or updated files.