Technical Overview

BaseSpace Clarity LIMS is built on a platform that is easy to customize and supports off-the-shelf hardware, common database systems, and industry-standard data formats.

We offer both on-premise and Illumina cloud hosted deployment models. Both offerings use the same underlying software and security model as explained in the BaseSpace Clarity LIMS Security and Privacy technical note, available for download from the Illumina website.

For on-premise deployments, we provide flexibility in selecting tools that suit your needs and existing IT infrastructure. The Clarity LIMS environment includes:

•

Application server

•

Database

•

File server

•

Web client

Depending on the details of your contract with Illumina, the environment can also include:

•

Automation Workers

For cloud deployments, the hardware is scaled upward by Illumina as required.

For on-premise deployments, you can separate application and file server functions from the database functions by installing them on discrete hardware platforms. Alternatively, you can combine them on a single server hardware platform. Base your decision on the size of your installation and how much data your laboratory processes.

Whichever solution you choose, Illumina requires that the Clarity LIMS server environment reside on dedicated hardware, free from other Illumina or third-party server products. The server environment must also be on a 1 Gbs or faster network. The network should not contain links with a capacity lower than 100 Mbps on any network-connected devices, such as routers, firewalls, and switches.

The Clarity LIMS installation installs Apache Tomcat 9.0, Apache Webserver v2 (used as a proxy), ElasticSearch and RabbitMQ to support search, and Open JDK 8.0. These software versions are the only versions that Clarity LIMS supports. The software packages are supplied by Illumina.

For Illumina cloud hosted deployments, Illumina fully manages the system deployment and maintenance.

Clarity LIMS uses a web application served by the Apache Tomcat server to manage the creation, collection, and retrieval of data and results. This core server is built on a Java architecture and allows for rapid deployment and custom configuration for other on-premise and Illumina cloud hosted deployments.

For both on-premise and Illumina cloud hosted deployments, the application requires the following standard secure ports for web and file communications:

•

Web communications: Port 80, 443

•

File communications: Port 22

Depending on included instrument integrations, additional open ports may be required.

For Illumina cloud hosted deployments, a site-to-site VPN connection, using IPSEC, might be required for instrument integrations. The most current list of required open ports is included in the preinstallation documentation that is provided during an implementation project.

Clarity LIMS supports PostgreSQL database to record data generated by the client, and references to file locations on the Clarity LIMS file server.

If the system needs to export a file, it issues a call to the database to find the file location on the file server. We recommend that you store files on a server or file system separate from the Clarity LIMS application server, such as a Network Attached Storage (NAS) appliance.

When handling data, Clarity LIMS saves files in their original format. The advantages of saving files in their original format are as follows:

•

The size of files is restricted only by the size of your file system.

•

You benefit from the built-in error-correction and integrity-checking features included in the file system.

The amount of storage space required by Clarity LIMS depends on the following:

•

The number of samples your laboratory processes each day.

•

The instruments you use.

•

The number of files you save to the Clarity LIMS system.

Illumina can work with you to recommend an appropriate amount of storage space.

User-centric, goal-based design has become the new standard in software interfaces. Clarity LIMS has a clean, helpful, easy-to-use interface. It is a lightweight web application that provides:

•

A simple, fast, and efficient way for lab scientists to identify work they need to complete.

•

The tools necessary to complete and record that work quickly and efficiently.

The Clarity LIMS Automation Worker allows specifically designed scripts to automate and extend the functionality of Clarity LIMS. You can integrate a wide variety of laboratory instruments and software.

The Automation Worker runs as a Windows Service or as a Linux daemon. You can install the Automation Worker on any computer with a supported OS on your Clarity LIMS network. When you install multiple copies on different machines on your network, Clarity LIMS automatically distributes work across the machines to improve system performance.

Mixpanel™ is a system that provides Illumina with information about how users interact with the Clarity LIMS web client. We do this by tracking which features are being used, and how often. Gathering this information allows us to determine which interactions are most common, and how our users proceed through protocol steps and tasks. We can then use this information to improve system performance and ultimately enhance the user experience.

All data are collected anonymously. We collect data on Clarity LIMS usage only. We do not collect specific sample names, projects, or values entered. We do track total usage (number of samples selected, how many protocol steps executed, and so on). Data are collected across all customers for analysis in one group. We do not directly track which site is doing which work. If you require more information about Mixpanel, contact the Illumina Support team.

All client traffic is encrypted over secure HTTP (HTTPS). To ensure the security of the transactions between Clarity LIMS and clients, on-premise deployments require a purchased certificate. The certificate should be from a well-known vendor such as DigiCert, Entrust, or QuoVadis. For information on the policies, processes, and controls enacted for security and privacy of data in Illumina cloud hosted deployments, see the Clarity LIMS Security and Privacy Technical Note, available for download from the Illuminawebsite.