Input Options

DRAGEN can process reads in FASTQ format or BAM/CRAM format. DRAGEN supports the following compression options for FASTQ input files.

Uncompressed
gzip or bgzip compression
ORA compression. To use ORA compression, you must provide an ORA reference and reference directory. See DRAGEN ORA Compression and Decompression.

If your input FASTQ files are gzipped, automatically decompresses the files using hardware-accelerated decompression, and then streams the reads into the mapper. If your files end in *.ora, DRAGEN automatically decompresses the files using ORA decompression, and then streams the reads into the mapper. The same FASTQ command line options apply for all compression formats.