Prepare a Reference Genome

Before a reference genome can be used with DRAGEN, the reference genome must be converted from FASTA format into a custom binary format. The options used in this preprocessing step offer tradeoffs between performance and mapping quality.

DRAGEN is shipped with reference genomes hg19 and GRCh37. Both reference genomes are preinstalled based on recommended settings for general applications. You can use the supplied reference genomes, or modify reference preprocessing command line options.