Illumina Annotation Engine
Illumina Annotation Engine (IAE), also known as Nirvana, provides clinical-grade annotation of genomic variants, such as SNVs, MNVs, insertions, deletions, indels, STRs, SV, and CNVs. Use a VCF as input. The output is a structured JSON representation of all annotations and sample information extracted from the VCF. IAE can handle multiple alternate alleles and multiple samples.
VCF files can be enabled by annotation on the DRAGEN command-line or by running the standalone tool.
Before running IAE, the external data sources, gene models, and reference genome need to be downloaded from the annotation server.
By default, the IAE binaries are located in the /opt/edico/share/nirvana directory. This directory includes two files: the Downloader and Nirvana (Illumina Annotation Engine).
